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Nose-to-Brain-patch

A breakthrough approach

Nose to Brain Delivery of Antibodies via the Olfactory Region for the Treatment of Multiple Sclerosis Using Novel Multifunctional Biomaterials Combined with a Medical Device

Our EU-funded research involves an innovative method of bypassing the blood brain barrier by delivering a potential MS drug with a special medical device via the nose directly to the brain!

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Welcome to the N2B-patch project

The N2B-patch project is an EU-funded project that started in January 2017. N2B-patch stands for Nose-to-Brain-patch. We aim to develop an innovative technology for multiple sclerosis (MS) treatment by developing a ‘nose to brain’ delivery system which will avoid the need for injections and oral medicine. The long-term objective is to improve treatment of MS patients.

 

N2B-patch - Final Video

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After 4,5 years, the N2B-patch project officially ends by the end of June 2021.

In a final project video, the consortium sheds light on the objectives, the challenges and the advantages that a direct transport route from the nasal cavity to the brain, bypassing the blood-brain barrier, could potentially offer for central nervous system drug delivery. Moreover, the latest results of the proof of concept study are presented by the N2B-patch team.

The further development of platform technology for the treatment of other CNS disorders continues beyond the end of the project.

Exciting innovation: Nose to Brain drug delivery

The direct transport route from the nasal cavity to the brain, bypassing the blood-brain barrier, could potentially offer an exciting method for central nervous system drug delivery. It may be used not only for demyelinating disorders such as MS but also for other neurological and neurodegenerative indications or tumours.

The N2B-patch team will deliver a proof of concept of its therapeutic potential as well as a preclinical validation. Science, industry and patients’ representatives work hand in hand in order to achieve the project objectives and maximise impact for patients and their relatives, health professionals and European industries. They are guided by regulatory and business exploitation experts.

 

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